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Study identifier: NCT07535463 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study of Ivonescimab, Chemotherapy, and Stereotactic Radiosurgery for People With Non-Small Cell Lung Cancer

Condition: Non-Small Cell Lung Cancer  ·  Sponsor: Memorial Sloan Kettering Cancer Center

PhasePhase 1/Phase 2
Planned participants53
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The researchers are doing this study to test the safety of ivonescimab given in combination with standard chemotherapy and stereotactic radiosurgery (SRS) in people with non-small cell lung cancer (NSCLC) that has spread to the brain (brain metastases). The researchers will test different doses of the study drug to find the best dose that causes few or mild side effects in participants. Once the dose is found, the researchers will test it in a new group of participants to see if it is effective in treating their NSCLC brain metastases.

This description comes directly from the study's public registry record.

Talk to the study team

Luke Pike, MD, PhD  ·  212-639-8157  ·  pikel@mskcc.org

Mark Awad, M.D., PhD  ·  646-608-2928

Always discuss trial participation with your own doctor first.

Locations (7)

Memorial Sloan Kettering Basking Ridge (All Protocol Activities)Basking Ridge, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Monmouth (All Protocol Activities)Middletown, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Bergen (All Protocol Activities)Montvale, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Suffolk - Commack (All Protocol Activities)Commack, New York, United StatesRecruiting
Memorial Sloan Kettering Westchester (All Protocol Activities)Harrison, New York, United StatesRecruiting
Memorial Sloan Kettering Cancer Center (All Protocol Activities)New York, New York, United StatesRecruiting
Memorial Sloan Kettering Nassau (All Protocol Activities)Rockville Centre, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07535463