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Study identifier: NCT07528365 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Urea for Treatment of Hyponatremia in Patients With SIAD Unresponsive to Fluid Restriction

Condition: SIAD - Syndrome of Inappropriate Antidiuresis  ·  Sponsor: University of Turin, Italy

PhaseNA
Planned participants20
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Hyponatremia due to SIAD is frequently insufficiently corrected by fluid restriction alone, which remains the first-line therapy but is often poorly tolerated. Urea supplementation is recommended as second-line therapy. This prospective study evaluates the effectiveness of oral urea supplementation in patients with chronic SIAD and persistent hyponatremia despite fluid restriction.

This description comes directly from the study's public registry record.

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Locations (1)

AOU Città della Salute e della ScienzaTurin, Piedmont, Italy, ItalyRecruiting

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Source record: clinicaltrials.gov/study/NCT07528365