Condition: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) · Sponsor: Regeneron Pharmaceuticals
This study will test a study drug called ALN-PNP with and without another drug that is used for controlling blood sugar, appetite, and weight (for example, tirzepatide), to see if it can help treat MASLD, also known as fatty liver disease. ALN-PNP reduces the amount of Patatin-like phospholipase domain-containing protein 3 (PNPLA3), a protein that liver cells make, which may help decrease liver fat if there is an abnormal PNPLA3 protein. The goal of this study is to understand the effect of ALN-PNP with or without tirzepatide on reducing liver fat. The study is looking at: * How well ALN-PNP with and without tirzepatide works * What side effects ALN-PNP might cause * How much ALN-PNP is in the blood at different times * How the body and the liver change after having ALN-PNP, which can help researchers understand why ALN-PNP works better in some people than others
This description comes directly from the study's public registry record.
Clinical Trials Administrator · 844-734-6643 · clinicaltrials@regeneron.com
Always discuss trial participation with your own doctor first.
| Southern California Research Center | Coronado, California, United States | Recruiting |
| California Liver Research Institute | Pasadena, California, United States | Recruiting |
| Tandem Clinical Research, Plaza II | Metairie, Louisiana, United States | Recruiting |
| Advanced Medical Trials | Georgetown, Texas, United States | Recruiting |
| American Research Corporation at The Texas Liver Institute | San Antonio, Texas, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07527910