Condition: Advanced Microsatellite Stable Colorectal Cancer · Sponsor: Gilead Sciences
The goal of this clinical study is to learn more about the study drug, Denikitug (DEN, GS-1811), to evaluate the efficacy and safety of Denikitug Monotherapy and Denikitug-based Combinations in participants with advanced microsatellite stable (MSS) colorectal cancer (CRC). The primary objective of this study is to assess the effect of DEN as monotherapy and in combination with nivolumab (NIVO) or trifluridine-tipiracil (FTD-TPI) and bevacizumab (BVZ) on objective response rate (ORR) as assessed by the investigator according to Response Evaluation Criteria in Solid Tumors (RECIST Version 1.1).
This description comes directly from the study's public registry record.
Gilead Clinical Study Information Center · 1-833-445-3230 (GILEAD-0) · GileadClinicalTrials@gilead.com
Always discuss trial participation with your own doctor first.
| Yale-New Haven Hospital - Yale Cancer Center | North Haven, Connecticut, United States | Recruiting |
| Beth Israel Deaconess Medical Center | Boston, Massachusetts, United States | Recruiting |
| Dana-Farber Cancer Institute | Boston, Massachusetts, United States | Active Not Recruiting |
| Washington University School of Medicine | St Louis, Missouri, United States | Not Yet Recruiting |
| Avera Cancer Institute | Sioux Falls, South Dakota, United States | Recruiting |
| University of Virginia, | Charlottesville, Virginia, United States | Recruiting |
| Chris O'Brien Lifehouse | Camperdown, CA, Australia | Recruiting |
| Royal Brisbane and Women's Hospital | Herston, Queensland, Australia | Recruiting |
| Peter MacCallum Cancer Centre | Melbourne, Victoria, Australia | Recruiting |
| Samsung Medical Center | Busan, South Korea | Not Yet Recruiting |
| Seoul National University Hospital | Seoul, South Korea | Not Yet Recruiting |
| Yonsei University Severance Hospital ( aka Yonsei Cancer Center) | Seoul, South Korea | Not Yet Recruiting |
+ 2 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT07527858