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Study identifier: NCT07527247 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Improving Vaccine Protection for Adults

Condition: Immune System Responses and Trained Immunity After AS01 Administration · Healthy Adult  ·  Sponsor: Singapore General Hospital

PhasePhase 2
Planned participants40
Who can joinAll sexes, 21 Years to 59 Years
Healthy volunteersYes

About this study

As people grow older, their immune system - the body's natural defence against diseases - becomes weaker, making them more vulnerable to infections and less responsive to vaccines. This was clearly seen during the COVID-19 pandemic, where older adults were more likely to develop severe illness. Researchers have made an interesting discovery about AS01, an ingredient already used in successful vaccines like the shingles vaccine. They found clues that AS01 might work like a general fitness trainer for the immune system, potentially making it stronger and better at fighting off various types of infections, not just specific ones. To confirm this possibility, we are conducting this research study with adults aged 21-59 to test whether AS01 by itself can boost and train the immune system, how long this boost lasts, and if it actually helps you fight off other infections more effectively.

This description comes directly from the study's public registry record.

Talk to the study team

Candice Y.Y. Chan, MBChB, MRCP  ·  +6563213479  ·  candice.chan.y.y@singhealth.com.sg

Christina Titin  ·  +6565762802  ·  christina.titin@singhealth.com.sg

Always discuss trial participation with your own doctor first.

Locations (1)

Singapore General HospitalSingapore, SingaporeRecruiting

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Source record: clinicaltrials.gov/study/NCT07527247