Condition: Alport Syndrome, X-Linked · Alport Syndrome, Autosomal Recessive · Sponsor: Eloxx Pharmaceuticals, Inc.
This is a randomized, double-Blind, placebo-controlled study to evaluate the efficacy and safety of exaluren in Alport Syndrome patients with nonsense mutations in COL4A3/4/5 genes. Targeted 24 patients aged 12 and older will be enrolled in the trial. The study will be comprised of the following periods for each participant: * a Screening period of up to 6 weeks (42 days) * a total Treatment Period of exaluren 0.75 mg/kg or placebo administered daily subcutaneously for 32 weeks: Part 1: patients are randomized to either exaluren or placebo for 16 weeks. Part 2: all patients across both randomized arms receive exaluren for 16 additional weeks. * a safety/efficacy Follow-up Period of 4 weeks after the last treatment
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
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| University of California, Los Angeles | Los Angeles, California, United States | Not Yet Recruiting |
| Stanford University | Stanford, California, United States | Not Yet Recruiting |
| Denver Nephrologists PC, Colorado Kidney Care PC | Denver, Colorado, United States | Recruiting |
| University of Minnesota | Minneapolis, Minnesota, United States | Not Yet Recruiting |
| Hackensack University Medical Center | Hackensack, New Jersey, United States | Not Yet Recruiting |
| Cleveland Clinic | Cleveland, Ohio, United States | Not Yet Recruiting |
| University of Pennsylvania | Philadelphia, Pennsylvania, United States | Not Yet Recruiting |
| Renal Associates, P.A. | San Antonio, Texas, United States | Not Yet Recruiting |
| Alder Hey Children's NHS Foundation Trust | Liverpool, United Kingdom | Not Yet Recruiting |
| Royal Free Hospital | London, United Kingdom | Recruiting |
| Great Ormond Street Hospital | London, United Kingdom | Recruiting |
| Royal Manchester Children's Hospital | Manchester, United Kingdom | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT07523581