Condition: Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia · Relapsed/Refractory B-cell Non-Hodgkin Lymphoma or CLL/SLL · Relapsed/Refractory Multiple Myeloma or Plasma Cell Leukemia · Sponsor: Beijing Biotech
Phase 1/2 umbrella study evaluates biomarker-selected dual-target CAR-T cell modules for adults with relapsed or refractory hematologic malignancies. After central antigen co-expression screening, participants are assigned to the most appropriate active dual-target module: CD19/CD22, CD19/CD20, BCMA/CD19, BCMA/CD38, BCMA/GPRC5D, CD33/CD123, CD33/CLL1, or CD5/CD7. Phase 1 determines safety, dose-limiting toxicities, and the recommended phase 2 dose for each module; phase 2 estimates preliminary antitumor activity, including overall response rate and MRD-negative response. Lymphodepletion with fludarabine/cyclophosphamide precedes infusion. The design is intended to reduce antigen escape by matching disease biology and target co-expression to a rational dual-target strategy.
This description comes directly from the study's public registry record.
shan S Lu, Phd · +86 13076790030 · Seni-Lu@beijing-biotech.com
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| Peking University Shenzhen Hospital | Shenzhen, Guangdong, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07523555