Condition: REFRACTORY SYSTEMIC LUPUS ERYTHEMATOSUS · Lupus Nephritis · Sponsor: Beijing Biotech
study evaluates a biomarker-guided strategy to assign adults with refractory SLE to autologous CAR-T therapy targeting either CD19 or BCMA. Participants undergo centralized screening immunophenotyping to determine whether their disease appears B-cell-dominant (CD19-preferred) or plasma-cell-dominant (BCMA-preferred), followed by leukapheresis, lymphodepletion, and a single CAR-T infusion. The main goals are to assess safety, determine a recommended Phase 2 dose within each arm, and estimate remission rates by Week 24.
This description comes directly from the study's public registry record.
shan S Lu, Phd · +86 13076790030 · Seni-Lu@beijing-biotech.com
Always discuss trial participation with your own doctor first.
| Peking University Shenzhen Hospital | Shenzhen, Guangdong, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07523542