Condition: Nephrotic Syndrome With Edema (Diagnosis) · Minimal Change Nephrotic Syndrome · Focal Segmental Glomerulosclerosis (FSGS) · Sponsor: Meyer Children's Hospital IRCCS
Nephrotic syndrome is a kidney condition that mainly affects children and is characterized by high levels of protein in the urine, low levels of protein in the blood, and swelling. While many children respond well to steroid treatment, a large proportion experience relapses or become dependent on therapy. In some cases, the disease does not respond to standard treatments and may progress to chronic kidney disease. Recent research suggests that, in addition to genetic factors, immune system mechanisms may play a key role in the development and progression of nephrotic syndrome. In particular, some patients produce autoantibodies against nephrin, an essential protein of the kidney filtration barrier. These autoantibodies may be associated with disease activity and treatment response. The aim of this study is to investigate the presence of anti-nephrin autoantibodies in children with nephrotic syndrome and to better understand their role in disease mechanisms and clinical outcomes.The study will also explore the presence of other autoantibodies targeting components of the glomerular filtration barrier. The study will use advanced laboratory techniques, including blood tests and detailed analysis of kidney biopsy samples, to identify these antibodies and their relationship with kidney structure and function. By integrating laboratory findings with clinical data, this study aims to improve the understanding of nephrotic syndrome and support the development of more personalized …
This description comes directly from the study's public registry record.
Paola Romagnani, MD, PhD · +39 0555662563 · paola.romagnani@meyer.it
Always discuss trial participation with your own doctor first.
| Mayo Clinic | Rochester, Minnesota, United States | Not Yet Recruiting |
| Ludwig-Maximilians Universitat | München, Germany | Not Yet Recruiting |
| Ospedale Santa Maria Annunziata | Bagno a Ripoli, Firenze, Italy | Not Yet Recruiting |
| Meyer Children's Hospital IRCCS | Florence, FIRENZE, Italy | Recruiting |
| IRCCS Azienda Ospedaliero - Universitaria | Bologna, Italy | Not Yet Recruiting |
| Azienda Ospedaliero Universitaria Careggi | Florence, Italy | Not Yet Recruiting |
| Ospedale S. Giovanni di Dio | Florence, Italy | Not Yet Recruiting |
| IRCCS Istituto Giannina Gaslini | Genova, Italy | Not Yet Recruiting |
| Azienda Ospedaliero-Universitaria di Parma | Parma, Italy | Not Yet Recruiting |
| Azienda Ospedaliero Universitaria Pisana | Pisa, Italy | Not Yet Recruiting |
| Ospedale Santo Stefano | Prato, Italy | Not Yet Recruiting |
| Azienda USL - IRCCS | Reggio Emilia, Italy | Not Yet Recruiting |
+ 2 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT07516964