Condition: Squamous Cell Carcinoma · Human Papilloma Virus (HPV) · Oropharyngeal Squamous Cell Carcinoma (OPSCC) · Sponsor: Medical University of South Carolina
This single-arm Phase II trial evaluates whether omission of postoperative radiotherapy is feasible and oncologically safe in select patients with HPV-associated oropharyngeal squamous cell carcinoma (HPV-OPSCC). Eligible patients undergo transoral robotic surgery (TORS) and are observed without adjuvant radiation if they demonstrate low or intermediate pathological risk features and have negative circulating tumor HPV DNA (ctHPVDNA) two weeks post-operatively. Patients are followed with standard clinical surveillance combined with serial ctHPVDNA testing (NavDx®) to facilitate early detection of recurrence and prompt salvage therapy as needed.
This description comes directly from the study's public registry record.
HCC Clinical Trials Office · 843-792-9321 · hcc-clinical-trials@musc.edu
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| Medical University of South Carolina | Charleston, South Carolina, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07513389