Condition: Head and Neck (HNSCC) · Sponsor: Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
The goal of this observational study is to learn whether a blood test can show the same biological features as the tumor in people with head and neck cancer that is not caused by HPV. These cancers often have different biological types, and these types may help predict how the cancer will behave. Today, these types can only be found by studying tumor tissue. This study wants to see if a simple blood sample can give the same information. The main questions the study aims to answer are: * Can a blood test identify the same tumor type that researchers find by studying tumor tissue under a microscope and through genetic testing? * Can these blood test results help predict how people may do after finishing treatment? Researchers will not assign treatments. All participants will receive the treatments recommended by their own care team as part of routine care. Participants will: * Give a blood sample before starting treatment. * Give another blood sample about 3 months after finishing treatment. * Allow researchers to use a sample of their tumor (already collected as part of standard care) for genetic testing. * Continue routine follow-up visits with their care team. About 300 adults with locally advanced, HPV-negative head and neck cancer (affecting the mouth, throat, voice box, or hypopharynx) will take part. Only people who are receiving treatment to cure their cancer can join. People with returning cancer or cancer that has already spread cannot join. Researchers will st…
This description comes directly from the study's public registry record.
Lisa Licitra · +39 02 2390 2810 · lisa.licitra@istitutotumori.mi.it
Stefano Cavalieri · stefano.cavalieri@istitutotumori.mi.it
Always discuss trial participation with your own doctor first.
| Fondazione IRCCS Istituto Nazionale dei Tumori | Milan, Italy | Recruiting |
| Azienda Ospedaliera Universitaria di Sassari | Sassari, Italy | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07512921