Condition: Critical Illness · Recovery Outcomes · Critical Care, Intensive Care · Sponsor: Lisbon Academic Medical Center - Centro Académico de Medicina de Lisboa
Persistent Critical Illness (PCI) is a condition that affects some patients who remain in the Intensive Care Unit (ICU) for a long time, usually more than 10-14 days. It is estimated to occur in 5-20% of critically ill patients. A recent Portuguese study found that more than 14% of ICU patients stayed longer than 14 days. PCI is often associated with ongoing need for life support, such as mechanical ventilation or medications to maintain blood pressure. However, patients may also experience severe muscle weakness, repeated infections, or other complications, which makes this group very diverse. One of the main risk factors for prolonged ICU stay is sepsis, a severe infection that affects the whole body. Other factors-such as prior health conditions, use of corticosteroids, sedation practices, early versus late mobilization, fluid and antibiotic management, and delirium treatment-may also influence the development and course of PCI. This study aims to identify different clinical patterns ("clusters") among critically ill patients who remain in the ICU for more than 10 days. Patients will be followed until hospital discharge, and up to one year if data are available. Understanding these different patterns will help develop more personalized and effective care strategies for each patient profile. The study is a multicenter retrospective cohort including adult patients (≥18 years) admitted to participating ICUs for more than 5 days between 2021 and 2023. Data collected will in…
This description comes directly from the study's public registry record.
Susana Fernandes, MD PhD. · 351 21 798 5100 · susanamfernandes@medicina.ulisboa.pt
Mariana Santos, PhD · 351 21 798 5100 · marianamsantos@medicina.ulisboa.pt
Always discuss trial participation with your own doctor first.
| Centro Hospitalar de São João / ULS São João | Lisbon, Lisbon District, Portugal | Recruiting |
| Hospital de Vila Franca de Xira / ULS Estuário do Tejo | Lisbon, Lisbon District, Portugal | Recruiting |
| Hospital Garcia de Orta / ULS Almada-Seixal | Lisbon, Lisbon District, Portugal | Recruiting |
| Hospital Prof. Doutor Fernando Fonseca / ULS Amadora -Sintra | Lisbon, Lisbon District, Portugal | Recruiting |
| Hospital Santa Maria / ULS Santa Maria | Lisbon, Lisbon District, Portugal | Recruiting |
| Hospital São Francisco Xavier / Centro Hospitalar de Lisboa Ocidental | Lisbon, Lisbon District, Portugal | Recruiting |
| Hospital de VIla Nova de Gaia-Espinho / ULS Gaia e Espinho | Vila Nova de Gaia, Porto District, Portugal | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT07510776