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Study identifier: NCT07510061 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Title: ICARUS - Psycho-physiological Profiling of Low and High Heat-resilient Individuals

Condition: Skin Cancer · Heat Tolerance · Heat-related Illness  ·  Sponsor: University of Thessaly

PhaseNA
Planned participants80
Who can joinAll sexes, 18 Years to 65 Years
Healthy volunteersYes

About this study

The escalating environmental heat-stress associated with global warming is a societal challenge with large and potential harmful consequences for humans. Excess morbidity and mortality during heat waves provides strong evidence for fatal outcomes. However, it is unclear why some people are particularly vulnerable and get sick from hyperthermia, while others adapt and tolerate exposure. The Icarus project aims to provide a psycho-physiological framework for improved mitigation of the health threats associated with global warming. Combining expertise in integrative thermal physiology, pharmacology, photobiology, psychology and machine learning, we will collaborate on comprehensive cross-scientific studies using controlled lab-exposure combined with investigations in ecological settings including vulnerable and highly tolerant people across populations from northern to southern Europe. Advanced algorithms will be developed to generate personalized alerts and advising based on behavioral patterns, psychological profiling, predicted vulnerability and willingness to adopt resilience-building strategies. Global warming is projected to continue towards the end of the 21st century and constitutes an increasing threat to human health unless we as individuals and collectively become better in preventing acute effects, as well as devise sustainable strategies to limit further anthropogenic warming of the climate system. Acutely, improved guidance is important for both individual and p…

This description comes directly from the study's public registry record.

Talk to the study team

Maria Vliora, PhD  ·  6979642540  ·  mvliora@gmail.com

Konstantinos Mantzios, PhD  ·  6948626874  ·  konstantinosmantzios@gmail.com

Always discuss trial participation with your own doctor first.

Locations (2)

Københavns UniversitetCopenhagen, DenmarkRecruiting
Department of Physical Education and Sport ScienceTrikala, Thessaly, GreeceRecruiting

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Source record: clinicaltrials.gov/study/NCT07510061