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Study identifier: NCT07500506 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study to Learn About the Safety, Tolerability, and Immunogenicity of a Fifth Dose of 6-Valent OspA-Based Lyme Disease Vaccine

Condition: Lyme Disease  ·  Sponsor: Pfizer

PhasePhase 3
Planned participants1712
Who can joinAll sexes, 7 Years to no upper limit
Healthy volunteersYes

About this study

The purpose of this study is to learn about the safety effects of the Lyme disease vaccine (called VLA15), and its ability to protect people from Lyme disease after a 5th dose of the vaccine. This study is seeking participants who: * are generally healthy and 7 years of age and older, * have already been vaccinated with 4 doses of VLA15 (from the VALOR study), and have blood sample taken post dose 4. * are not currently taking, or haven't recently taken, medicines like chemotherapy, blood products, or blood thinners. * are not pregnant or breastfeeding and do not plan to become pregnant while receiving the study vaccine. All participants in this study will receive a total of 1 dose through a shot in the upper arm, either VLA15 or saline shot (saltwater). The study will compare the experiences of people receiving the study vaccine or saltwater shot. Participants will take part in this study for about 12 months. During this time, they will have 4 planned clinic visits. The clinic visits may include having a health check, giving a small amount of blood and getting the study vaccine or saltwater as a shot at the first visit.

This description comes directly from the study's public registry record.

Talk to the study team

Pfizer CT.gov Call Center  ·  1-800-718-1021  ·  ClinicalTrials.gov_Inquiries@pfizer.com

Always discuss trial participation with your own doctor first.

Locations (22)

Northern Light Eastern Maine Medical CenterBangor, Maine, United StatesNot Yet Recruiting
Northern Light Family Medicine and Residency CenterBangor, Maine, United StatesNot Yet Recruiting
University of Massachusetts Chan Medical SchoolWorcester, Massachusetts, United StatesRecruiting
Hunterdon Medical CenterFlemington, New Jersey, United StatesNot Yet Recruiting
Smith Allergy and Asthma SpecialistsCortland, New York, United StatesRecruiting
Smith Allergy & Asthma SpecialistsHorseheads, New York, United StatesRecruiting
Altoona Center For Clinical ResearchDuncansville, Pennsylvania, United StatesRecruiting
Allegheny Health and Wellness PavilionErie, Pennsylvania, United StatesRecruiting
Central Erie Primary CareErie, Pennsylvania, United StatesRecruiting
Preferred Primary Care Physicians, Preferred Clinical Research (Ofc 18)Pittsburgh, Pennsylvania, United StatesRecruiting
Preferred Primary Care Physicians, Preferred Clinical Research - St.ClairPittsburgh, Pennsylvania, United StatesNot Yet Recruiting
Robert Packer HospitalSayre, Pennsylvania, United StatesRecruiting

+ 10 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07500506