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Study identifier: NCT07499661 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Pulmonary Embolism in Patients With Acute Heart Failure (PEHF Study)

Condition: Acute Heart Failure (AHF) · Pulmonary Embolism (Diagnosis) · Venous Thromboembolism  ·  Sponsor: University Hospital, Angers

PhaseNA
Planned participants740
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study focuses on two serious and common medical conditions: heart failure and pulmonary embolism (a blood clot in the lungs). Heart failure happens when the heart cannot pump blood effectively, and it is one of the main reasons older adults are admitted to the hospital. Pulmonary embolism can be life-threatening and may worsen heart failure or even trigger it. Doctors believe that pulmonary embolism may often go undetected in patients who come to the hospital with symptoms of acute heart failure, such as sudden shortness of breath. This is because both conditions can cause similar symptoms, making it difficult to tell them apart. As a result, doctors may sometimes assume the symptoms are only due to heart failure and not investigate further for a possible blood clot. However, missing a pulmonary embolism can have serious consequences. Studies suggest that some patients with heart failure who die may actually have had an undiagnosed pulmonary embolism. Current medical guidelines recommend checking for pulmonary embolism when the cause of breathing problems is unclear, but in real-life practice, this is not always done. The goal of this study is to find out whether pulmonary embolism is underdiagnosed in patients with suspected acute heart failure and whether systematically testing for it could improve patient outcomes. To do this, the study will compare two approaches in several hospitals. In half of the hospitals, doctors will follow their usual practice and decide c…

This description comes directly from the study's public registry record.

Talk to the study team

Delphine Douillet, Professor  ·  +33 (0)2 41 35 36 27  ·  Delphine.Douillet@chu-angers.fr

Matthieu Le Lay  ·  +33 (0)2 41 35 58 91  ·  DRCI-Promotion-Interne@chu-angers.fr

Always discuss trial participation with your own doctor first.

Locations (10)

Agen Hospital, Emergency departmentAgen, FranceNot Yet Recruiting
Angers University Hospital, Emergency DepartmentAngers, FranceRecruiting
Brest University Hospital (site Cavale Blanche), Cardiology DepartmentBrest, FranceNot Yet Recruiting
Tours University Hospital (site Trousseau), Adult Emergency DepartmentChambray-lès-Tours, FranceNot Yet Recruiting
Cholet Hospital, Emergency DepartmentCholet, FranceNot Yet Recruiting
Clermont-Ferrand University Hospital, Emergency DepartmentClermont-Ferrand, FranceNot Yet Recruiting
Grenoble Alpes University Hospital, Adult Emergency DepartmentLa Tronche, FranceNot Yet Recruiting
Lyon University Hospital (site Edouard Herriot), Emergency DepartmentLyon, FranceNot Yet Recruiting
Poitiers University Hospital, Emergency DepartmentPoitiers, FranceNot Yet Recruiting
Toulouse University Hospital, Emergency DepartmentToulouse, FranceNot Yet Recruiting

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Source record: clinicaltrials.gov/study/NCT07499661