Condition: Breast Cancer Risk · Ovarian Cancer Risk · Cancer Gene Mutation · Sponsor: Queen Mary University of London
PROTECT-C is a research study offering genetic testing to people to see whether they have a genetic change that increases their risk of breast, ovary, bowel, and/or womb cancer. This is regardless of whether they or their families have had cancer. Breast, ovary, bowel, and womb cancers make up half of all cancers in women. Around 15-20% (15 to 20 in 100 cases) of ovary and 3-4% (3 to 4 in 100 cases) of breast, womb, and bowel cancers are linked to cancer genes and may be prevented. People with a genetic change that puts them at increased risk of any of these cancers have ways to help them manage their risk through the NHS. This may include screening to find cancers earlier when they are easier to treat, and surgery or medication to prevent cancers from developing. This can save lives. Currently, genetic testing is only available on the NHS to people who meet certain criteria. For example, those who have had certain cancers, have a strong family history of cancer, or those with Jewish ancestry. But many people may not have a strong family history or meet NHS testing criteria. This means that this system of testing misses 50% to 80% of people (50 to 80 in 100 people) who have a genetic change. It is thought that only around 3 in 100 people overall who have a genetic change that increases their risk of cancer know about it. Given the effective screening and preventive options that are available, this represents a huge, missed opportunity to prevent cancers or find them earlier…
This description comes directly from the study's public registry record.
Ranjit Manchanda, PhD · +44 8008620236 · r.manchanda@qmul.ac.uk
Caitlin Fierheller, PhD · +44 8008620236 · protectc.study@qmul.ac.uk
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| Wolfson Institute of Population Health, Queen Mary University of London | London, United Kingdom | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07498829