Condition: Bladder Cancer · Urothelial Carcinoma · Metastatic Urothelial Carcinoma · Sponsor: Beijing Biotech
This hypothetical first-in-human study is designed to evaluate the safety, feasibility, and preliminary anti-tumor activity of an allogeneic dual-target Nectin-4/HER2 CAR-NK cell product in adults with relapsed/refractory locally advanced or metastatic urothelial carcinoma. Based on public urothelial-cancer evidence, Nectin-4 was selected as the lead antigen because it has the strongest disease-specific clinical validation; HER2/ERBB2 was chosen as the secondary co-target to broaden tumor coverage and reduce antigen-escape risk. EpCAM is not selected as a therapeutic co-target in this example because of broader normal epithelial expression and weaker tumor specificity in urothelial carcinoma.
This description comes directly from the study's public registry record.
Seni S Lu, Phd · +86 13076790030 · Seni-Lu@beijing-biotech.com
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| Peking University Shenzhen Hospital | Shenzhen, Guangdong, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07492628