Condition: Heart Failure With Reduced Ejection Fraction · Sponsor: University of Michigan
The purpose of this trial is to better understand how the beta-blocker metoprolol works in people with Heart Failure with Reduced Ejection Fraction (HFrEF) according to participants genetics. Participants will have the beta-blocker (BB) polygenic score calculated from genotype data. The score will be used to stratify the patients in the low and high polygenic score groups in the study. The hypotheses for this trial are: * HFrEF patients with high polygenic score will have weaker cardiovascular responses to metoprolol succinate than HFrEF patients with low polygenic score. * HFrEF patients with high polygenic score have lower steady-state plasma concentrations of metoprolol succinate than HFrEF patients with low polygenic score. * HFrEF patients with high polygenic score require higher metoprolol succinate plasma concentrations to achieve similar cardiovascular effects as those with low polygenic score.
This description comes directly from the study's public registry record.
Diamond Thomas · 734-615-4532 · diamthom@med.umich.edu
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| University of Michigan | Ann Arbor, Michigan, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07490067