Condition: EBV-associated T/NK-cell Lymphoproliferative Diseases · Refractory/Relapsed EBV-related Hemophagocytic Lymphohistiocytosis · Letermovir · Sponsor: Beijing Children's Hospital
This study investigates the impact of letermovir prophylaxis on viral infections (including CMV, EBV, BKV, HHV-6/7, RSV, ADV, HSV, etc.) following allogeneic hematopoietic stem cell transplantation in pediatric patients with EBV-associated T/NK-cell lymphoproliferative diseases and refractory/relapsed EBV-related hemophagocytic lymphohistiocytosis. Additionally, we examine its effects on other transplantation complications, including engraftment failure, graft-versus-host disease (GvHD), disease relapse, thrombotic microangiopathy (TMA), overall survival (OS), post-transplant lymphoproliferative disorder (PTLD) incidence, and immune reconstitution.
This description comes directly from the study's public registry record.
Jun Yang, Doctor · +86 13699293825 · yangjundabby@outlook.com
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| Beijing Children's Hospital, Capital Medical University | Beijing, Beijing Municipality, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07488728