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Study identifier: NCT07488676 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study of ASP546C in Adults With Gastroesophageal Cancer, Pancreatic Cancer or Other Solid Tumors

Condition: Gastric or Gastro-esophageal Junction (GEJ) Adenocarcinoma · Pancreatic Adenocarcinoma  ·  Sponsor: Astellas Pharma Global Development, Inc.

PhasePhase 1/Phase 2
Planned participants150
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study will help find the most suitable dose of ASP546C in people with gastric cancer, gastroesophageal junction (GEJ) cancer, pancreatic cancer, and other specific solid tumors. GEJ is where the food pipe (esophagus) joins the stomach. This study is in 2 parts. In both parts of the study, ASP546C will be given once in 3-week cycles. It will be given slowly through a tube into a vein. This is called an infusion. In Part 1, people with gastric cancer or GEJ cancer can take part. They will receive an infusion of either a higher dose or a lower dose of ASP546C. In Part 2, people with pancreatic cancer or who have one of the other solid tumors can take part. Part 2 doesn't include people with gastric cancer or GEJ cancer. All people in this part of the study will receive an infusion of the higher dose of ASP546C. People will visit the clinic on certain days to receive ASP546C and have health checks. The number of visits and checks done during the study will depend on the health of each person and whether they are still receiving infusions of ASP546C.

This description comes directly from the study's public registry record.

Talk to the study team

Astellas Pharma Global Development, Inc  ·  800-888-7704  ·  Astellas.registration@astellas.com

Always discuss trial participation with your own doctor first.

Locations (14)

UAB Medicine - UAB HospitalBirmingham, Alabama, United StatesRecruiting
START Los AngelesLos Angeles, California, United StatesRecruiting
Indiana University (IU) Health - Multi-D Oncology ClinicIndianapolis, Indiana, United StatesRecruiting
START MidwestGrand Rapids, Michigan, United StatesRecruiting
START New YorkLake Success, New York, United StatesRecruiting
Duke Cancer Center DurhamDurham, North Carolina, United StatesRecruiting
Next Oncology - AustinAustin, Texas, United StatesRecruiting
Next Oncology - HoustonHouston, Texas, United StatesRecruiting
Next Oncology - DallasIrving, Texas, United StatesRecruiting
START San AntonioSan Antonio, Texas, United StatesRecruiting
START Mountain RegionWest Valley City, Utah, United StatesRecruiting
National Cancer Center Hospital EastKashiwa-shi, Chiba, JapanRecruiting

+ 2 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07488676