Condition: Provoked Vestibulodynia · Sponsor: Center for Vulvovaginal Disorders
This is a double-blind, placebo-controlled study evaluating the safety and efficacy of incobotulinumtoxinA (Merz) for the treatment of provoked vestibulodynia (PVD) associated with overactive pelvic floor muscle dysfunction. Eligible participants are premenopausal females aged 18 years and older with a confirmed diagnosis of PVD with hypertonic pelvic floor muscles, established by both an expert physician and an expert pelvic floor physical therapist. Participants must have bilateral provoked pain at the posterior vestibule on cotton swab testing and a pain score of 5 or greater on an 11-point Numeric Rating Scale (NRS) during standardized dilator testing at baseline. Key outcome measures include change in pain during dilator testing and Patient Global Impression of Change (PGI-C). Participants with anterior vestibular pain, prior botulinum toxin injection in the genitopelvic area within the past 12 months, or significant genitourinary conditions that may confound assessment are excluded.
This description comes directly from the study's public registry record.
Andrew Goldstein, MD · 202-887-0568 · obstetrics@yahoo.com
Always discuss trial participation with your own doctor first.
| Center for VulvoVaginal Disorders | Washington D.C., District of Columbia, United States | Recruiting |
| Centers for Vulvovaginal Disorders, NY | New York, New York, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07486830