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Study identifier: NCT07483099 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study of LY4395089 and Mirikizumab (LY3074828) Given Together and Mirikizumab (Alone) in Adults With Crohn's Disease

Condition: Crohn Disease  ·  Sponsor: Eli Lilly and Company

PhasePhase 2
Planned participants60
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersNo

About this study

The main purpose of this study is to see how the safety and efficacy of a farnesoid X receptor (FXR) agonist (LY4395089), given together with mirikizumab compares with mirikizumab (alone) in adults with moderately to severely active Crohn's disease (CD). This study is part of the IIBD master protocol and will last approximately 62 weeks.

This description comes directly from the study's public registry record.

Talk to the study team

There may be multiple sites in this clinical trial. (Add "This 1-877-CTLILLY (1-877-285-4559) or  ·  1-317-615-4559  ·  clinical_inquiry_hub@lilly.com

Always discuss trial participation with your own doctor first.

Locations (71)

Mayo Clinic in Arizona - ScottsdaleScottsdale, Arizona, United StatesNot Yet Recruiting
Biopharma Informatic, LLCLos Angeles, California, United StatesNot Yet Recruiting
Om Research LLCOxnard, California, United StatesRecruiting
South Denver GastroenterologyEnglewood, Colorado, United StatesRecruiting
Gastro Health Research - MiamiMiami, Florida, United StatesNot Yet Recruiting
Ezy Medical ResearchMiami Lakes, Florida, United StatesRecruiting
Atlanta Gastroenterology Associates - Peachtree DunwoodyAtlanta, Georgia, United StatesRecruiting
Rush University Medical CenterChicago, Illinois, United StatesNot Yet Recruiting
Cotton O'Neil Digestive Health CenterTopeka, Kansas, United StatesRecruiting
Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinical Research CenterWyoming, Michigan, United StatesNot Yet Recruiting
KAD Clinical ResearchSt Louis, Missouri, United StatesNot Yet Recruiting
Vector Clinical TrialsLas Vegas, Nevada, United StatesRecruiting

+ 59 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07483099