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Study identifier: NCT07480590 Synced from ClinicalTrials.gov · July 29, 2026
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GLOW: Gender-Affirming Care and Mental Health: A Longitudinal Study On Quality of Life, Work Life, and Healthcare Outcomes

Condition: Gender Dysphoria, Adult  ·  Sponsor: Region Skane

PhaseN/A
Planned participants500
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Gender-Affirming Care and Mental Health (GLOW) investigates the psychological, medical, and social factors that influence the outcomes of gender-affirming care, as well as its impact on mental health, work capacity, and quality of life. Gender dysphoria is defined as the incongruence of a person's experienced gender and sex assigned at birth. In Sweden, the prevalence of gender dysphoria has increased significantly in recent decades. Still there is no consensus on the long-term outcomes ofgender-affirming care. 1. What are the baseline characteristics in individuals seeking gender-affirming care and do any of these predict outcomes of gender-affirmative care?2. Do individuals with gender dysphoria experience improved or reduced quality of life, gender congruence, or functional capacity after gender-affirming care?3. Does gender-affirming care reduce or increase psychiatric symptoms and self-concept clarity?4. What are the effects of gender-affirming care on mortality, work capacity, and healthcare resource utilization as compared to an age and gender matched control group?Data and MethodGLOW targets patients at the Gender Dysphoria Clinic, Region Skåne a National Highly Specialized Care unit (NHV). Mixed methods will be used to analyze data from national registries and self-reported assessments.The NHV status ensures standardized high-quality data collection and clinical follow-up, making this project a unique opportunity to evaluate the care given to individuals with gender …

This description comes directly from the study's public registry record.

Talk to the study team

Emma Claesdotter-Knutsson, MD; Ass prof  ·  +46768871765  ·  emma.claesdotter-knutsson@regionskane.se

Always discuss trial participation with your own doctor first.

Locations (1)

The Gender Dysphoria Clinic at Skåne University Hospital, Malmö, SwedenMalmö, Malmö, SwedenRecruiting

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Source record: clinicaltrials.gov/study/NCT07480590