Condition: PONV · Cerebellopontine Angle Tumor · Microvascular Decompression Surgery · Sponsor: Xuanwu Hospital, Beijing
This single-center, double-blind, randomized controlled trial aims to determine whether oliceridine for patient-controlled intravenous analgesia (PCIA) can significantly reduce the incidence of postoperative nausea, an opioid-related adverse reaction, compared to sufentanil PCIA in patients undergoing cerebellopontine angle (CPA) region surgery. A secondary objective is to compare the postoperative analgesic effects between the two drugs. The study plans to enroll 174 patients (with a calculated sample size of 164 plus 5% for attrition). The primary outcome is the incidence of nausea within 6-48 hours postoperatively. Secondary outcomes include pain scores at rest and during movement within 48 hours, and other exploratory outcomes such as vomiting incidence, time to first flatus/defecation, and gastrointestinal function scores.
This description comes directly from the study's public registry record.
Wei Xiao, Dr. · +86-13810971299 · kitten15@126.com
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| Xuanwu Hospital, Capital Medical University | Beijing, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07479446