Condition: STEMI - ST Elevation Myocardial Infarction · Sponsor: Thomas Engstrom
BACKGROUND Myocardial reperfusion with the use of primary percutaneous coronary intervention (PCI) including stent implantation is the most efficacious treatment for patients with (STEMI) and improves prognosis significantly. Due to continuous improvements in the treatment, the mortality for patients with STEMI has decreased dramatically, but despite these improvements, the mortality rate seems to have reached a plateau at around 10% within 1 year. In addition, 10% develop clinical heart failure with a per se 50% mortality rate within 5 years. Moreover, congestive heart failure is associated with a highly impaired quality of life due to fatigue dyspnea and reduced exercise capacity. Thus, there is a need for further improvement in the treatment to drive the event rates further down. One such key target is reducing the damage to the heart muscle (infarct size) to preserve the heart function and prevent mortality and heart failure. One major driver of infarct size and mortality is reperfusion injury which may account for up to 50% of the damaged myocardium. Reperfusion injury occurs within the first minutes to hours after the restoration of the blood flow in the occluded artery and reperfusion therapy can therefore be considered a "double-edged sword", since the ischemic injury may additionally be worsened by reperfusion injury. However, the phenomenon of reperfusion injury is not completely understood, and no preventive treatments exist. Multiple pathophysiological factors may…
This description comes directly from the study's public registry record.
Jacob Lønborg, MD, PhD, DMSc · 35458176 · Jacob.Thomsen.Loenborg.01@regionh.dk
Jasmine M Marquard, MD · +4560197827 · jasmine.melissa.marquard@regionh.dk
Always discuss trial participation with your own doctor first.
| Aalborg University Hospital | Aalborg, Denmark | Not Yet Recruiting |
| Skejby, Aarhus University Hospital | Aarhus, Denmark | Not Yet Recruiting |
| Rigshospitalet | Copenhagen, Denmark | Recruiting |
| Odense University Hospital | Odense, Denmark | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT07478003