Condition: Neurological Disorders · Health Adult Subjects · Sponsor: Istituti Clinici Scientifici Maugeri SpA
Despite the improvements in life expectancy, neurodegenerative diseases (NDGs) have become the most dreaded disorders of older people. Aged brains show characteristic changes that are linked to neurodegeneration raising the question of whether these hallmarks represent the harbingers of NDGs. Lifestyle factors including, in particular physical exercise, have given particular attention to factors associated to movement issue as ones of the major factors in modulating the risk of developing NDGs, emphasizing the interest in the muscle-brain axis. Indeed, one of the crucial systems severely affected in several neuromuscular diseases is the loss of effective connection between muscle and nerve, and the neuromuscular junction (NMJ) represents the critical region at the level of which the two entities communicate. Even if controversy exists on whether pathological events beginning at the NMJ precede or follow loss of motor units, some recent data highlight as NGDs (e.g. Amyotrophic Lateral Sclerosis, Alzheimer's Disease, and Parkinson's Disease) and Aging share some common pathologic features such as the loss of fast-twich fiber, a decreased number of synaptic vesicles and sarcopenia giving evidence supports the notion that NMJ dismantlement can occur independently from motor neuron degeneration and may represent an early pathogenic signature of muscle-nerve communication defects. The M-Brain project is an observational, analytical case-control study that will apply a new approac…
This description comes directly from the study's public registry record.
Christian Lunetta, MD · +39 0250725266 · christian.lunetta@icsmaugeri.it
Davide Sattin, PsyD, PhD · +390250725246 · davide.sattin@icsmaugeri.it
Always discuss trial participation with your own doctor first.
| Universita degli Studi di Catania | Catania, Italy | Active Not Recruiting |
| IRCCS Centro Neurolesi Bonino Pulejo | Messina, Italy | Recruiting |
| Istituti Clinici Scientifici Maugeri IRCCS, Milan Institute | Milan, Italy | Recruiting |
| University of Roma La Sapienza | Roma, Italy | Active Not Recruiting |
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Source record: clinicaltrials.gov/study/NCT07477821