Condition: Prostate Cancer (Post Prostatectomy) · Radiotherapy; Image-Guided · Prostate Cancer Non-Metastatic · Sponsor: Sun Yat-sen University
The goal of this clinical trial is to evaluate whether the addition of pelvic radiotherapy to androgen deprivation therapy (ADT) can delay disease progression and improve survival outcomes in patients with pathologically confirmed regional lymph node-positive (pN1) prostate cancer after radical prostatectomy. The main questions it aims to answer are: * Does ADT combined with pelvic radiotherapy improve biochemical recurrence-free survival (bRFS) compared with ADT alone in pN1 patients? * Does the addition of pelvic radiotherapy improve clinical progression-free survival, metastasis-free survival, overall survival, and prostate cancer-specific survival without unacceptable toxicity? Researchers will compare ADT plus pelvic radiotherapy with ADT alone to see if combined treatment improves disease control and long-term clinical outcomes. Participants with positive lymph nodes after prostatectomy will be randomly assigned in a 2:1 ratio to receive ADT plus pelvic radiotherapy, or ADT alone. ADT will be administered for 2 years. Patients with radiologically detectable pelvic recurrence or distant metastases after radical prostatectomy will be excluded. Safety, adverse events, and health-related quality of life will be assessed during follow-up.
This description comes directly from the study's public registry record.
Liru He, PhD · +862087343030 · helir@sysucc.org.cn
Yang Liu, MD · +862087341521 · liuyang1@sysucc.org.cn
Always discuss trial participation with your own doctor first.
| Dongguan People's Hospital | Dongguan, Guangdong, China | Not Yet Recruiting |
| Sun Yat-sen University Cancer Center | Guangzhou, Guangdong, China | Recruiting |
| The First Affiliated Hospital of Guangzhou Medical University | Guangzhou, Guangdong, China | Not Yet Recruiting |
| The First Affiliated Hospital, Sun Yat-sen University | Guangzhou, Guangdong, China | Not Yet Recruiting |
| Affiliated Hospital of Guangdong Medical University | Zhanjiang, Guangdong, China | Not Yet Recruiting |
| Henan Cancer Hospital | Zhengzhou, Henan, China | Recruiting |
| West China Hospital, Sichuan University | Chengdu, Sichuan, China | Recruiting |
| The First Affiliated Hospital, Zhejiang University School of Medicine | Hangzhou, Zhejiang, China | Not Yet Recruiting |
| Beijing Hospital | Beijing, China | Recruiting |
| Cancer Hospital, Chinese Academy of Medical Sciences | Beijing, China | Not Yet Recruiting |
| Peking University First Hospital | Beijing, China | Recruiting |
| Peking University Third Hospital | Beijing, China | Not Yet Recruiting |
+ 1 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT07477626