Condition: Healthy Participants · Anxiety Disorders (With High Anxiety Symptoms) · Depressive Disorders (With High Anhedonia Symptoms) · Sponsor: Dr. Nils B. Kroemer
This study investigates if anhedonia and anxiety symptoms are associated with alterations in reinforcement learning, effort trade-offs for wins vs. punishments, and foraging behavior under threat. Moreover, it will investigate whether these processes can be influenced by a metabolic load and/or transcutaneous vagus nerve stimulation (tVNS). The project consists of (a) an online reinforcement learning study, used to characterize learning, reward sensitivity, and meta-cognition, and (b) a laboratory study in which participants first undergo fMRI while completing an effort-based decision-making task. Second, participants will complete two sessions in VR with randomized active or sham tVNS during a foraging task before and after a caloric load with concurrent physiological recordings.
This description comes directly from the study's public registry record.
Dr. Anne Kühnel · +49 228 28711519 · akuehnel@uni-bonn.de
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| University Hospital Bonn, Bonn, Germany | Bonn, Germany | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07476469