Condition: Rectal Cancer, Adenocarcinoma · Sponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
This is a single-center, exploratory clinical study for patients with newly diagnosed, high-risk, locally advanced rectal cancer. The study aims to evaluate the effectiveness and safety of a comprehensive pre-surgery (neoadjuvant) treatment strategy. All participants will receive a short course of radiation therapy (25 Gy in 5 fractions) over one week. This will be followed by a combination of chemotherapy (Liposomal Irinotecan, Oxaliplatin, and Capecitabine) and immunotherapy (Sintilimab). This combined treatment is administered for six cycles. For patients who achieve a complete response, the option to avoid immediate surgery and enter a close monitoring program ("Watch and Wait") will be considered.
This description comes directly from the study's public registry record.
Hongli Liu, Professor · 13995680822 · hongli_liu@hust.edu.cn
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| Hongli Liu | Wuhan, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07474103