Condition: Cardiac Surgery Patient · Postoperative Pain · Pain After Surgery · Sponsor: Istanbul University - Cerrahpasa
Ethics committee approval was obtained for this study, which was planned as a prospective, randomized, controlled, single-center trial to be conducted in patients undergoing coronary artery bypass grafting (CABG) surgery between December 2025 and March 2026. Patients eligible for inclusion were randomized into two groups at a 1:1 ratio using a random number list generated via the random.org website. Randomization was performed by an independent investigator who was not involved in the study procedures. The allocation sequence was placed into sequentially numbered, opaque, sealed envelopes. Upon enrollment of each patient, the next numbered envelope was opened to determine group assignment. Patients who did not complete the study protocol or did not receive the allocated medication were excluded from the analysis, and a per-protocol analysis approach was applied. The randomization list was kept confidential and was accessible only to authorized statistical personnel. Patients were followed in two groups: the Control Group (Group C) and the Morphine Group (Group M). All procedures were performed at the Istanbul University-Cerrahpaşa Cardiology Institute. After obtaining written informed consent, all patients were transferred to the operating room, where an 18G intravenous cannula was inserted, followed by premedication with midazolam 0.03 mg/kg (IV). Standard monitoring included 5-lead electrocardiography (ECG), heart rate measurement, invasive arterial blood pressure monit…
This description comes directly from the study's public registry record.
Yasemin Ozsahin, Specialist M.d. · +905369256721 · yasemin.ozsahin@iuc.edu.tr
Kerem Erkalp, Professor · +90 532 787 95 00 · kerem.erkalp@iuc.edu.tr
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| Istanbul University -Cerrahpasa Institute of Cardiology | Istanbul, Outside of the US, Turkey (Türkiye) | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07472959