Condition: Paracetamol · Hypotension Drug-Induced · Emergency Surgery · Sponsor: Cairo University
Emergency laparotomy is a high-risk procedure often performed in patients with severe physiological derangements due to sepsis, making perioperative management challenging. Although multimodal analgesia is essential, options are often limited by factors such as hemodynamic instability, renal dysfunction, and coagulopathy. Intravenous paracetamol is commonly recommended for perioperative analgesia because of its opioid-sparing effect, but evidence suggests it may cause hypotension through peripheral vasodilation, particularly in critically ill patients. Most data on this effect come from observational studies, and evidence regarding its intraoperative hemodynamic impact remains limited.
This description comes directly from the study's public registry record.
Maha Mostafa · +201000365115 · maha.mostafa@cu.edu.eg
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| Cairo University | Cairo, Cairo Governorate, Egypt | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07466108