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Study identifier: NCT07465276 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Neoadjuvant Ficerafusp Alfa With Pembrolizumab in Resectable SCC

Condition: Head and Neck Squamous Cell Carcinoma (HNSCC) · Squamous Cell Carcinoma of the Head and Neck  ·  Sponsor: Dana-Farber Cancer Institute

PhasePhase 2
Planned participants32
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This trial is to evaluate the safety and efficacy of ficerafusp alfa in combination with pembrolizumab prior to surgical resection in participants with resectable, high-risk, locoregionally advanced, PD-L1-positive squamous cell carcinoma of the head and neck (HNSCC). The names of the study drugs used in this research study are: * ficerafusp alfa (a type of bifunctional antibody and recombinant fusion protein) * pembrolizumab (a type of monoclonal antibody)

This description comes directly from the study's public registry record.

Talk to the study team

Glenn Hanna  ·  617-632-3779  ·  Gjhanna@partners.org

Glenn Hanna

Always discuss trial participation with your own doctor first.

Locations (2)

Brigham and Women's HospitalBoston, Massachusetts, United StatesRecruiting
Dana-Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07465276