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Study identifier: NCT07464925 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Phase 1 Safety and Dose Finding Study of GLIX1 in Adults With Recurrent or Progressive High-grade Glioma

Condition: Glioblastoma Multiforme of Brain · Glioma · Glioblastoma  ·  Sponsor: Tetragon Biosciences Ltd

PhasePhase 1
Planned participants30
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is an open-label, multicenter dose-escalation study to be followed by a dose expansion to define the optimal dose of GLIX1 as monotherapy by reviewing safety and tolerability, disease characteristics and pharmacokinetic profiles and preliminary clinical activity in participants with a high grade diffuse glioma that progressed during or recurred after prior standard of care therapies or investigational therapies as clinically indicated. Patients will be treated daily with GLIX1 capsules until disease progression or unacceptable safety.

This description comes directly from the study's public registry record.

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Contact details are listed per location below or on the registry record.

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Locations (3)

Moffitt Cancer CenterTampa, Florida, United StatesRecruiting
Northwestern MedicineChicago, Illinois, United StatesNot Yet Recruiting
NYU Langone HealthNew York, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07464925