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Study identifier: NCT07464860 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Feasibility of Breathwork Intervention With Older Adults After Knee Surgery

Condition: Surgical Stress Response · Stress Physiological · Stress Physiology  ·  Sponsor: University of Arizona

PhaseNA
Planned participants32
Who can joinAll sexes, 65 Years to no upper limit
Healthy volunteersYes

About this study

Postoperative complications after surgical procedures, including following total knee arthroplasty (TKA), have a negative impact on the health and well-being of surgical patients. Older adults (≥65 years) are particularly vulnerable to postoperative complications and their associated morbidities due to the biological aging process. Older adults comprise nearly half of surgical patients worldwide, and this number is expected to increase in the next 10-20 years as the aging population continues to grow. TKA is the most common procedure undergone by older adults, and the rate of TKA procedures is also expected to rise. Despite perioperative guidelines and protocols to prevent postoperative complications, the prevalence of postoperative complications following TKA is approximately 12%. Given these statistics, millions of older adults undergoing TKA may be at risk for postoperative complications and their associated morbidities in the coming decades. Therefore, additional interventions are needed to combat postoperative complications in this population. The body's natural response to surgery, also known as the surgical stress response (SSR), contributes to postoperative complications through complex mechanisms involving the autonomic nervous system (ANS). Increased sympathetic nervous system (SNS) activity, or the body's fight-or-flight response, causes dysregulation in feedback systems that regulate the stress response, potentially leading to poorer outcomes. Interventions, such…

This description comes directly from the study's public registry record.

Talk to the study team

Devon E Cobos Garcia, PhD Candidate, MS, BSN  ·  904-477-7960  ·  decg0131@arizona.edu

Always discuss trial participation with your own doctor first.

Locations (1)

The University of ArizonaTucson, Arizona, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07464860