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Study identifier: NCT07463183 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study to Evaluate Efficacy and Safety of MK-8690 in Participants With Moderately to Severely Active Ulcerative Colitis (MK-8690-002)

Condition: Colitis Ulcerative · Ulcerative Colitis  ·  Sponsor: Merck Sharp & Dohme LLC

PhasePhase 2
Planned participants100
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

The purpose of this protocol is to evaluate the efficacy of MK-8690 in participants with moderately to severely active ulcerative colitis. The primary hypothesis is that MK-8690 is superior to placebo with respect to the proportion of participants achieving clinical remission per Modified Mayo Score at Week 12.

This description comes directly from the study's public registry record.

Talk to the study team

Toll Free Number  ·  1-888-577-8839  ·  Trialsites@msd.com

Always discuss trial participation with your own doctor first.

Locations (15)

Clinnova Research ( Site 1042)Anaheim, California, United StatesRecruiting
Peak Gastroenterology Associates ( Site 1052)Colorado Springs, Colorado, United StatesRecruiting
South Denver Gastroenterology, PC ( Site 1068)Englewood, Colorado, United StatesRecruiting
Nature Coast Clinical Research ( Site 1045)Inverness, Florida, United StatesRecruiting
Research Associates of South Florida - Miami - Southwest 8th Street ( Site 1072)Miami, Florida, United StatesRecruiting
Gastroenterology Associates of Central Georgia ( Site 1060)Macon, Georgia, United StatesRecruiting
University of Kansas Medical Center ( Site 1077)Kansas City, Kansas, United StatesRecruiting
Tulane University School of Medicine ( Site 1073)New Orleans, Louisiana, United StatesRecruiting
BVL Research - Kansas ( Site 1054)Liberty, Missouri, United StatesRecruiting
Radboudumc ( Site 1650)Nijmegen, Gelderland, NetherlandsRecruiting
EB Group Sp. Z o.o. Centrum Zdrowia MDM ( Site 1449)Warsaw, Masovian Voivodeship, PolandRecruiting
Medical Network Spółka z o.o. WIP Warsaw IBD Point Profesor Kierkuś ( Site 1448)Warsaw, Masovian Voivodeship, PolandRecruiting

+ 3 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07463183