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Study identifier: NCT07456046 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Phase 1 Study of D3S-003 as Monotherapy in Participants With Advanced Solid Tumors With a KRAS p.G12D Mutation.

Condition: KRAS P.G12D  ·  Sponsor: D3 Bio (Wuxi) Co., Ltd

PhasePhase 1
Planned participants42
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a first-in-human (FIH) multicenter, open-label, dose-escalation Phase 1 clinical trial to evaluate safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary efficacy of D3S-003 in participants with advanced KRAS p.G12D mutant solid tumors.

This description comes directly from the study's public registry record.

Talk to the study team

Medical Director  ·  +86 21 61635900  ·  D3bio_CT@d3bio.com

Always discuss trial participation with your own doctor first.

Locations (5)

D3 Bio Investigative Site 1402San Antonio, Texas, United StatesRecruiting
D3 Bio Investigative Site 1103Randwick, New South Wales, AustraliaRecruiting
D3 Bio Investigative Site 1201Seoul, South KoreaRecruiting
D3 Bio Investigative Site 1203Seoul, South KoreaRecruiting
D3 Bio Investigative Site 1202Seoul, South KoreaRecruiting

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Source record: clinicaltrials.gov/study/NCT07456046