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Study identifier: NCT07455578 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Study of S-4321 in Participants With an Autoimmune or Immune-mediated Disease

Condition: Autoimmune Diseases · Rheumatoid Arthritis (RA) · Psoriatic Arthritis (PsA)  ·  Sponsor: Seismic Therapeutic AU Pty Ltd

PhasePhase 1
Planned participants24
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

This is a multi-center, open-label Ph 1b basket study to assess safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), immunogenicity, biomarker response, and preliminary efficacy of multiple doses of S-4321 in adults with autoimmune or immune-mediated disease including rheumatoid arthritis (RA), psoriatic arthritis (PsA), psoriasis (PsO), cutaneous lupus erythematosus (CLE) with or without systemic manifestations, or atopic dermatitis (AD).

This description comes directly from the study's public registry record.

Talk to the study team

Seismic Contact  ·  1800 244 475  ·  clinical@seismictx.com

Always discuss trial participation with your own doctor first.

Locations (2)

NovatrialsCharlestown, New South Wales, AustraliaRecruiting
University of the Sunshine Coast Clinical Trials, BirtinyaBirtinya, Queensland, AustraliaRecruiting

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Source record: clinicaltrials.gov/study/NCT07455578