Condition: Sepsis · Septic Shock · Sepsis - to Reduce Mortality in the Intensive Care Unit · Sponsor: Chinese University of Hong Kong
Sepsis is a life-threatening condition caused by the body's dysregulated response to an infection. While corticosteroids are known to help stabilize blood pressure in septic shock, their ability to reduce mortality is still debated. Recent analyses suggest that combining fludrocortisone with hydrocortisone may be more effective at saving lives than hydrocortisone alone. To test this hypothesis, a large, definitive international trial is needed. However, this research proposal is for a smaller pilot study (Phase II) involving 32 critically ill patients. The primary goal of this pilot is to determine the feasibility of conducting the subsequent large-scale trial that would compare hydrocortisone alone against the combination therapy and potentially change medical practice.
This description comes directly from the study's public registry record.
Lowell Ling, MBBS · (852) 35052735 · lowell.ling@cuhk.edu.hk
Always discuss trial participation with your own doctor first.
| North District Hospital | Hong Kong, Hong Kong | Not Yet Recruiting |
| Pamela Youde Nethersole Hospital | Hong Kong, Hong Kong | Not Yet Recruiting |
| Prince of Wales Hospital | Hong Kong, Hong Kong | Recruiting |
| Princess Margaret Hospital | Hong Kong, Hong Kong | Not Yet Recruiting |
| Queen Mary Hospital | Hong Kong, Hong Kong | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT07451886