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Study identifier: NCT07446868 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Ultrasound-Guided SPSIP Versus ESPB for Postoperative Pain After Modified Radical Mastectomy

Condition: Breast Cancer · Postoperative Pain · Acute Post-surgical Pain  ·  Sponsor: Cairo University

PhaseNA
Planned participants50
Who can joinFemale, 18 Years to 65 Years
Healthy volunteersNo

About this study

Breast cancer is the most common cancer affecting women worldwide. Modified radical mastectomy is one of the main surgical treatments for breast cancer. However, this surgery is often associated with significant postoperative pain, which may delay recovery and increase the need for opioid medications such as morphine. Regional anesthesia techniques are increasingly used to improve pain control after breast surgery and reduce opioid consumption. The erector spinae plane block (ESPB) is a well-established ultrasound-guided technique that provides effective chest wall analgesia. The serratus posterior superior intercostal plane (SPSIP) block is a newer ultrasound-guided technique that targets intercostal nerves and may provide effective postoperative pain relief. The purpose of this randomized clinical trial is to compare the effectiveness of SPSIP block versus ESPB block in controlling pain after modified radical mastectomy. The primary outcome will be total morphine consumption during the first 24 hours after surgery. Secondary outcomes include pain scores, time to first request for rescue analgesia, hemodynamic stability, recovery profile, patient satisfaction, and postoperative side effects such as nausea and vomiting. This study aims to determine whether the newer SPSIP block provides comparable or superior pain control to ESPB, with the goal of improving postoperative recovery and reducing opioid requirements in breast cancer patients.

This description comes directly from the study's public registry record.

Talk to the study team

Sayed M Abed, MD  ·  +20 122 680 6532  ·  sayed.abed@nci.cu.edu.eg

Sara F Ali, MSc  ·  +20 111588521  ·  Sarafarghaly1234@gmail.com

Always discuss trial participation with your own doctor first.

Locations (1)

National Cancer Institute - Cairo UniversityCairo, Cairo Governorate, EgyptRecruiting

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Source record: clinicaltrials.gov/study/NCT07446868