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Study identifier: NCT07446855 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Study of AZD4956 as Monotherapy and in Combination With Anti-Cancer Agents in Participants With Advanced/Metastatic Homologous Recombination Deficient Solid Tumours

Condition: Solid Tumours  ·  Sponsor: AstraZeneca

PhasePhase 1/Phase 2
Planned participants180
Who can joinAll sexes, 18 Years to 130 Years
Healthy volunteersNo

About this study

The purpose of this modular, first trial in human study is to assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary efficacy of ascending dose levels (DLs) of AZD4956 monotherapy and in combination with other anti-cancer agents in participants with advanced/metastatic solid tumours with homologous recombination repair (HRR) deficiencies.

This description comes directly from the study's public registry record.

Talk to the study team

AstraZeneca Clinical Study Information Center  ·  1-877-240-9479  ·  information.center@astrazeneca.com

Always discuss trial participation with your own doctor first.

Locations (19)

Research SiteNew York, New York, United StatesNot Yet Recruiting
Research SiteProvidence, Rhode Island, United StatesNot Yet Recruiting
Research SiteHouston, Texas, United StatesNot Yet Recruiting
Research SiteFairfax, Virginia, United StatesRecruiting
Research SiteMelbourne, AustraliaNot Yet Recruiting
Research SiteWestmead, AustraliaNot Yet Recruiting
Research SiteChūōku, JapanNot Yet Recruiting
Research SiteKashiwa, JapanNot Yet Recruiting
Research SiteSeoul, South KoreaNot Yet Recruiting
Research SiteSeoul, South KoreaNot Yet Recruiting
Research SiteBarcelona, SpainNot Yet Recruiting
Research SiteBarcelona, SpainNot Yet Recruiting

+ 7 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07446855