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Study identifier: NCT07444814 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Study Evaluating the Safety and Efficacy of HWK-007, a PTK7-directed Antibody Drug Conjugate in Participants With Advanced Solid Tumors

Condition: Endometrial Cancer · Ovarian Cancer · Ovarian Cancer Metastatic  ·  Sponsor: Whitehawk Therapeutics, Inc.

PhasePhase 1
Planned participants226
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

HWK-007-101 is a multicenter, open-label, first-in-human (FIH) Phase 1 study evaluating HWK-007, a protein tyrosine kinase 7 (PTK7)-targeted antibody drug conjugate (ADC), in adult participants with advanced or metastatic solid tumors known to be expressing PTK7. The study employs a sequential dose escalation and dose expansion design without a control group.

This description comes directly from the study's public registry record.

Talk to the study team

Clinical Trial Manager Lead  ·  888-392-9025  ·  WHWK-Clinical-Trials@whitehawktx.com

Central email mailbox - Whitehawk Therapeutics  ·  WHWK-Clinical-Trials@whitehawktx.com

Always discuss trial participation with your own doctor first.

Locations (12)

University of ArkansasLittle Rock, Arkansas, United StatesNot Yet Recruiting
UCLA - Hematology/Oncology Clinical Research UnitLos Angeles, California, United StatesNot Yet Recruiting
St. Francis Medical Center (OSF Healthcare)Peoria, Illinois, United StatesNot Yet Recruiting
START - MidwestGrand Rapids, Michigan, United StatesRecruiting
Hackensack University Medical Center - John Theurer Cancer CenterHackensack, New Jersey, United StatesNot Yet Recruiting
Roswell Park Comprehensive Care CenterBuffalo, New York, United StatesNot Yet Recruiting
University Hospital - Cleveland Medical CenterCleveland, Ohio, United StatesNot Yet Recruiting
NEXT Oncology - AustinAustin, Texas, United StatesRecruiting
NEXT - Oncology - HoustonHouston, Texas, United StatesRecruiting
START - San AntonioSan Antonio, Texas, United StatesRecruiting
NEXT Oncology - Virginia Cancer SpecialistsFairfax, Virginia, United StatesRecruiting
Fred Hutchinson Cancer CenterSeattle, Washington, United StatesNot Yet Recruiting

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Source record: clinicaltrials.gov/study/NCT07444814