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Study identifier: NCT07442812 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Oral vs Intravenous Dexamethasone in Total Knee Arthroplasty

Condition: Knee Osteoarthritis · Gonarthrosis; Primary · Total Knee Arthroplasty  ·  Sponsor: Haseki Training and Research Hospital

PhaseN/A
Planned participants270
Who can joinAll sexes, 50 Years to 80 Years
Healthy volunteersNo

About this study

This prospective observational cohort study aims to evaluate the association between perioperative dexamethasone administration and early postoperative recovery following primary total knee arthroplasty. In routine clinical practice, dexamethasone may be administered orally, intravenously, or not administered, depending on the surgeon's established perioperative protocol. The primary objective is to assess early postoperative recovery in terms of pain intensity, functional mobility, and knee joint range of motion. Secondary objectives include evaluation of inflammatory response, postoperative metabolic changes, opioid requirement, and the severity of postoperative nausea and vomiting (PONV). Group allocation is non-randomized and determined solely by the standard perioperative management approach routinely applied by the surgeon selected by the patient. No additional interventions are introduced for research purposes. All outcomes are assessed prospectively during the early postoperative period.

This description comes directly from the study's public registry record.

Talk to the study team

Atahan Eryilmaz, Resident Physician  ·  +90 552 609 9055  ·  dratahaneryilmaz@gmail.com

Mehmet Ersin, Associate Professor  ·  +90 507 788 60 54  ·  drmehmetersin@gmail.com

Always discuss trial participation with your own doctor first.

Locations (1)

Sultangazi Haseki Training and Research HospitalIstanbul, Istanbul, Turkey (Türkiye)Recruiting

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Source record: clinicaltrials.gov/study/NCT07442812