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Study identifier: NCT07441785 Synced from ClinicalTrials.gov · July 29, 2026
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Immediate and Functional Results of Different Types of Reconstructions After Proximal Gastrectomy For Gastric and Esophagogastric Junction Cancer

Condition: Gastric Cancer (GC) · Siewert Type III Adenocarcinoma of Esophagogastric Junction · Siewert Type II Adenocarcinoma of Esophagogastric Junction  ·  Sponsor: P. Herzen Moscow Oncology Research Institute

PhaseN/A
Planned participants400
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Proximal gastric and esophagogastric junction cancers comprise up to 40% of gastric malignancies. For localized disease, proximal gastrectomy is the main radical procedure, but reconstruction of GI tract often leads to significant functional issues. Rising use of proximal resections and broader indications have increased attention to postoperative quality of life (QoL). Common reconstructions include direct esophagogastrostomy (various types), double-tract reconstruction, jejunal interposition, and newer anti-reflux anastomoses (e.g., double-flap, overlap, tunnel techniques). Each method has unique pros and cons regarding reflux esophagitis, food passage, dumping syndrome, nutritional changes, and long-term QoL. No consensus exists on the optimal technique, leading to variable practices and outcomes. Most research focuses on oncologic radicality and survival, while functional results and QoL remain understudied. Systematic evaluation of functional outcomes across reconstruction types after proximal subtotal gastrectomy is needed in Russian Federation to improve QoL, advance research, and standardize treatment of proximal gastric and EGJ cancers.

This description comes directly from the study's public registry record.

Talk to the study team

Andrey Ryabov, MD, PhD  ·  +7 (495) 150-11-22  ·  ryabovdoc@mail.ru

Always discuss trial participation with your own doctor first.

Locations (1)

P.Herzen Moscow Oncological Research InstituteMoscow, RussiaRecruiting

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Source record: clinicaltrials.gov/study/NCT07441785