Condition: Mild Cognitive Impairment (MCI) · Sponsor: University of Texas at Austin
Cognitive reserve refers to the brain's ability to maintain cognitive performance despite age-related changes or neuropathology. Enhancing cognitive reserve is thought to delay cognitive decline and improve functional outcomes in aging and neurodegenerative conditions. Attention and memory-related neural processes are considered key contributors to cognitive reserve, yet it remains unclear whether these neural markers can be deliberately strengthened through targeted training and non-invasive interventions. The goal of this clinical study is to investigate whether mindfulness-based meditation and non-invasive brain stimulation can enhance neural markers of attention and memory that serve as proxies for cognitive reserve in cognitively healthy adults and older adults diagnosed with mild cognitive impairment (MCI). Investigators hypothesize that strengthening these neural markers will lead to measurable improvements in cognitive reserve-related functions in both healthy aging and MCI populations. This study further hypothesizes that neural markers of attention can be selectively enhanced using an electroencephalography (EEG)-based brain-computer interface (BCI) combined with non-invasive interventions such as mindfulness-based relaxation or neuromodulation. During the study, participants will perform a computerized memory task while their EEG signals are recorded in real time. A BCI will analyze these signals to decode the presence or absence of the P300 event-related potenti…
This description comes directly from the study's public registry record.
Jose del R. Millan, PhD · 512-232-8111 · jose.millan@austin.utexas.edu
Khushi Thorat · 512-495-5521 · BrainFit@austin.utexas.edu
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| The University of Texas at Austin | Austin, Texas, United States | Recruiting |
| Sun City | Georgetown, Texas, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07441122