Condition: Chronic Stroke Patient · Motor Impairment · Neurorehabilitation · Sponsor: School of Health Sciences Geneva
Stroke is one of the leading causes of long-term disability worldwide. Many individuals who survive a stroke continue to experience weakness and reduced control of one arm, even months or years after the event. These motor impairments significantly affect independence, daily activities, and quality of life. Despite rehabilitation efforts, recovery of upper limb function remains incomplete for many patients. Motor recovery after stroke depends on the brain's ability to reorganize itself, a process known as neuroplasticity. Recent research suggests that motor learning and brain recovery are influenced not only by activity in the primary motor cortex (M1), but also by its functional connectivity with other brain regions, particularly the parietal cortex (PC). Strengthening communication between these regions may enhance motor recovery. This study aims to investigate a novel, non-invasive brain stimulation approach called intermittent theta-burst stimulation (iTBS). Unlike traditional stimulation methods that target a single brain region, this study uses a multifocal stimulation protocol targeting both the primary motor cortex and the parietal cortex. The stimulation is combined with structured motor training using an interactive tablet-based rehabilitation device (REAtouch®Lite 2), designed to improve arm movement through goal-directed reaching tasks. The study is a single-center, randomized, sham-controlled, triple-blind clinical trial with parallel groups. Thirty-six indivi…
This description comes directly from the study's public registry record.
Pierre Nicolo, PhD · +41792633543 · pierre.nicolo@hesge.ch
Nicolas Nicastro, MD · +41 22 372 36 24 · nicolas.nicastro@hug.ch
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| University School of Health ▪ HES-SO Genève | Carouge, Canton of Geneva, Switzerland | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07439367