Condition: Heart Failure · Sponsor: Istanbul University - Cerrahpasa
Acute decompensated heart failure is a leading cause of hospitalization and is associated with high morbidity and mortality. Early risk stratification in this population is crucial for guiding treatment strategies and predicting short- and long-term clinical outcomes. Transthoracic echocardiography is routinely performed in patients hospitalized with acute decompensated heart failure and provides comprehensive information regarding cardiac structure and function. However, the prognostic value of detailed echocardiographic parameters obtained before the initiation of intravenous diuretic therapy has not been fully clarified. The objective of this prospective study is to evaluate the prognostic significance of transthoracic echocardiographic findings obtained at hospital admission, prior to intravenous diuretic therapy, in patients hospitalized with acute decompensated heart failure. The study will assess key echocardiographic parameters reflecting left and right heart structure and function, including left ventricular ejection fraction, left ventricular dimensions and geometry, left atrial size and volume, indices of right ventricular systolic function (such as TAPSE, tissue Doppler-derived S' velocity, and fractional area change), pulmonary artery systolic pressure, right ventricular-pulmonary artery coupling assessed by the TAPSE/PASP ratio, and right ventricular outflow tract acceleration time. Primary outcome measures include in-hospital mortality, post-discharge mortali…
This description comes directly from the study's public registry record.
Aybike G Taşdelen Acar, MD · +905356955610 · aybikegul.tasdelen@iuc.edu.tr
Ümit Acar, MD · +905424421411 · umit.acar1@iuc.edu.tr
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| Istanbul University Cerrahpaşa Institute of Cardiology | Istanbul, Turkey (Türkiye) | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07439159