Condition: Endometrial Endometrioid Adenocarcinoma · Endometrial Hyperplasia · Sponsor: New Mexico Cancer Research Alliance
This phase II trial tests compares the effect of progestins, megestrol acetate to micronized progesterone, in treating patients with endometrial cancer and precancers of the uterus (atypical endometrial hyperplasia) before surgery. Progestins, similar to the natural hormone progesterone, are approved drugs used in birth control and hormone replacement pills, and some can treat uterine endometrial cancers. In the initial comparison of this rotating umbrella trial, megestrol acetate, a progestin, will be compared to micronized progesterone, a form of natural progesterone that is a hormone produced by body normally. Hormone therapy using megestrol acetate and micronized progesterone may be effective in treating patients with endometrial cancer or atypical endometrial hyperplasia before surgery, and understanding the tissue effects of each agent on the malignant endometrium will uncover novel mechanistic and biomarker data to understand how best to advanced hormone therapy for endometrial cancer.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
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| University of Iowa/Holden Comprehensive Cancer Center | Iowa City, Iowa, United States | Recruiting |
| University of New Mexico Cancer Center | Albuquerque, New Mexico, United States | Recruiting |
| University of Utah Sugarhouse Health Center | Salt Lake City, Utah, United States | Not Yet Recruiting |
| University of Virginia Cancer Center | Charlottesville, Virginia, United States | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT07436793