Condition: Pulmonary Embolism (Diagnosis) · Pulmonary Embolism Acute · Sponsor: Azienda ULSS 8 Berica
Pulmonary embolism (PE) is the third leading cause of cardiovascular mortality worldwide. Current guidelines recommend early reperfusion for high-risk and intermediate-high-risk PE, yet systemic thrombolysis and percutaneous therapies are frequently underutilized, and no specific timing for reperfusion is defined, unlike in acute myocardial infarction or ischemic stroke. As most PE-related in-hospital deaths occur within the first hours and thrombus composition changes over time, defining an optimal reperfusion time window may improve survival and prevent hemodynamic deterioration. We therefore propose a national, multicenter, prospective observational study to evaluate the prognostic impact of reperfusion timing, using systemic thrombolysis or catheter-directed therapies, on in-hospital mortality and haemorrhagic or cardiovascular complications.
This description comes directly from the study's public registry record.
Claudio Bilato, MD PhD · +390444479106 · claudio.bilato@aulss8.veneto.it
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| IRCCS Policlinico San Matteo | Pavia, Pavia, Italy | Recruiting |
| UO di Sezione di Medicina Interna e Cardiovascolare, Ospedale Santa Maria della Misericordia, Perugia, Italia | Perugia, Perugia, Italy | Recruiting |
| UO di Cardiologia 1, Azienda Ospedaliero Universitaria Pisana, Pisa, Italia | Pisa, Pisa, Italy | Recruiting |
| UO di Cardiologia, Azienda Ospedaliera Ordine Mauriziano di Torino | Torino, Torino, Italy | Recruiting |
| UOC di Cardiologia, Ospedali dell'Ovest Vicentino, Arzignano, IItalia | Arzignano, Vicenza, Italy | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07436702