Condition: Schizophrenia Disorder · Schizoaffecitve Disorder · Aggression · Sponsor: Manhattan Psychiatric Center
The study investigates whether a virtual reality-based mindfulness based intervention can reduce impulsive aggression in individuals with schizophrenia or schizoaffective disorder. The primary goal is to evaluate whether mindfulness delivered via VR (MBI-VR) improves emotion regulation and engages the dorsomedial prefrontal cortex (dmPFC), a brain region involved in cognitive control and regulation of emotional responses. The study also examines whether these effects show a dose-related relationship. Participants will be randomized to receive different doses of MBI-VR intervention or distraction tasks and will complete repeated mindfulness VR sessions. Brain activity will be measured using functional magnetic resonance imaging (fMRI) during an emotion regulation task, along with clinical assessments of impulsive aggression related symptoms.
This description comes directly from the study's public registry record.
Anzalee Khan, PhD · 646-766-5876 · anzalee.khan@nki.rfmh.org
Benedicto Parker · 212-961-8992 · Benedicto.Parker@nki.rfmh.org
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| Manhattan Psychiatric Center | New York, New York, United States | Recruiting |
| NewYork-Presbyterian/Weill Cornell Medical Center Westchester Division | White Plains, New York, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07434479