Condition: Diarrhea Infectious · Shigella · Growth & Development · Sponsor: Johns Hopkins Bloomberg School of Public Health
The purpose of this study is to evaluate whether antibiotic treatment of non-dysentery Shigella associated watery diarrhea (NDSD) cases improves clinical outcomes and growth in children. Children with NDSD seeking care for diarrhea at the study hospitals in Bangladesh and Zambia will be enrolled and randomized to receive Azithromycin or placebo (a look-alike substance that contains no drug). Enrolled children will be followed for three months with household visits. The investigators will determine whether antibiotic treatment of NDSD reduces the duration of diarrhea and time to microbiological cure (shedding of Shigella in stool), and whether it improves growth in children compared with the placebo group.
This description comes directly from the study's public registry record.
Subhra Chakraborty, PhD, MPH, MSc · 410-502-3154 · schakr11@jhu.edu
Melissa Higdon, MPH · mhigdon@jhu.edu
Always discuss trial participation with your own doctor first.
| icddr,b Matlab Hospital | Chāndpur, Bangladesh | Not Yet Recruiting |
| icddr,b Hospital | Dhaka, Bangladesh | Recruiting |
| Matero Level 1 Hospital | Lusaka, Zambia | Not Yet Recruiting |
| Arthur Davidson Children's Hospital | Ndola, Zambia | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT07433426